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  Article Nature juillet 2009

par une equipe Japonaise

samedi 1er août 2009, par Alex

Article en anglais.

Most human infections with swineorigin H1N1 influenza viruses (S-OIVs) seem to be mild ; however,a substantial number of hospitalized individuals do not have underlying health issues, attesting to the pathogenic potential of S-OIVs.

To achieve a better assessment of the risk posed by the new virus, we characterized one of the first US S-OIV isolates, A/California/04/09 (H1N1 ; hereafter referred to as CA04), as well as several other S-OIV isolates, in vitro and in vivo. In mice and ferrets, CA04 and other S-OIV isolates tested replicate more efficiently than a currently circulating human H1N1 virus.

In addition, CA04 replicates efficiently in non-human primates, causes more severe pathological lesions in the lungs of infected mice, ferrets and non-human primates than a currently circulating human H1N1 virus, and transmits among ferrets. In specificpathogen- free miniature pigs, CA04 replicates without clinical symptoms.

The assessment of human sera from different age groups suggests that infection with human H1N1 viruses antigenically closely related to viruses circulating in 1918 confers neutralizing antibody activity to CA04. Finally, we show that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.

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